Universitą degli studi di Pavia
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Barillą's curriculum
Curriculum
Personal informations
Barillą Cristina
Birth: 04/08/1990 Vercelli, 13100, Vc, Italy
e-mail: cristina.barilla01@ateneopv.it
Education
Period: from 03/11/2014
Course: PhD course in Genetics, Molecular and Cellular Biology
Structure: University of Pavia. Department of Molecular Medicine, Via Forlanini 14, 27100 Pavia (Pv), Italy
Period: 01/10/2012-18/09/2014
Course: Sperimental and applied biology
Structure: University of Pavia. Department of Biology and Biothecnology “Lazzaro Spallanzani”
Thesis: Not common deletions in 16q24.3: genotype-phenotype correlation
Results: 110 cum laude
Period: 1/10/2009-13/12/2012
Course: Biological sciences
Structure: University of Piemonte Orientale “Amedeo Avogadro”
Thesis: Cytogenetics and molecular testing to diagnose the Fragile X syndrome
Results: 110 cum laude
Professional qualification: admission to Italian association of Biologist, November 2014
Professional experiences
Period: 25/11/2013-31/07/2014
Role: trainee student
Activity: Mutational analysis with NGS and Sanger Sequencing
Structure: Department of Molecular Medicine, Via Forlanini 14, 27100 Pavia (Pv), Italy
Period: 01/08/2012-2/11/2012
Role: treinee student
Activity: Karyotyping
Structure: Hospital center SS. Antonio e Biagio e C. Arrigo, Via Venezia 16, 15100 Alessandria (Al), Italy
Technical skills
Optical microscopy
Genomic DNA extraction
Pcr and Sanger sequencing
Analysis of chromatograms
Computer skills
Office
Genomic databases (i.e. UCSC) and prediction softwares (i.e. MutationTester)
Programs to design primers
Programs to analyze sequences and microsatellites
Languages
First language: Italian
Other: English and French
Publications
Research Project
Genotype-phenotype correlation and mutational analysis: two different approaches to study the pathogenetic processes
New high sensitivity technologies, like the array-CGH (Comparative Genomic Hybridization), identify in a more accurate and reliable way the genes involved in several pathological phenotypes. The introduction of high-throughput technologies, like the Exome sequencing, ensure a more operative and complete screening about deleterious genic alterations. My project mainly relates to the genotype-phenotype correlation, with possible functional studies to make clear the pathogenetic role in candidate genes found with different analytic strategies like array-CGH, NGS (Next-Generation Seguencing) and Sanger sequencing. In this regard, we are planning to study the role of MEG3 (maternally expressed gene 3) and MEG8 (maternally expressed gene 8) (14q32.2) in gene activation and embryonic differentiation. These genes encode for imprinted long non-coding RNA. The aim is to induce pluripotent stem cells from controls and patients with CNV in 14q32.2 fibroblasts to differentiate them in different tissues and then study the expression levels. This research could make clear their role in embryogenesis.
Personal informations
Barillą Cristina
Birth: 04/08/1990 Vercelli, 13100, Vc, Italy
e-mail: cristina.barilla01@ateneopv.it
Education
Period: from 03/11/2014
Course: PhD course in Genetics, Molecular and Cellular Biology
Structure: University of Pavia. Department of Molecular Medicine, Via Forlanini 14, 27100 Pavia (Pv), Italy
Period: 01/10/2012-18/09/2014
Course: Sperimental and applied biology
Structure: University of Pavia. Department of Biology and Biothecnology “Lazzaro Spallanzani”
Thesis: Not common deletions in 16q24.3: genotype-phenotype correlation
Results: 110 cum laude
Period: 1/10/2009-13/12/2012
Course: Biological sciences
Structure: University of Piemonte Orientale “Amedeo Avogadro”
Thesis: Cytogenetics and molecular testing to diagnose the Fragile X syndrome
Results: 110 cum laude
Professional qualification: admission to Italian association of Biologist, November 2014
Professional experiences
Period: 25/11/2013-31/07/2014
Role: trainee student
Activity: Mutational analysis with NGS and Sanger Sequencing
Structure: Department of Molecular Medicine, Via Forlanini 14, 27100 Pavia (Pv), Italy
Period: 01/08/2012-2/11/2012
Role: treinee student
Activity: Karyotyping
Structure: Hospital center SS. Antonio e Biagio e C. Arrigo, Via Venezia 16, 15100 Alessandria (Al), Italy
Technical skills
Optical microscopy
Genomic DNA extraction
Pcr and Sanger sequencing
Analysis of chromatograms
Computer skills
Office
Genomic databases (i.e. UCSC) and prediction softwares (i.e. MutationTester)
Programs to design primers
Programs to analyze sequences and microsatellites
Languages
First language: Italian
Other: English and French
Publications
Research Project
Genotype-phenotype correlation and mutational analysis: two different approaches to study the pathogenetic processes
New high sensitivity technologies, like the array-CGH (Comparative Genomic Hybridization), identify in a more accurate and reliable way the genes involved in several pathological phenotypes. The introduction of high-throughput technologies, like the Exome sequencing, ensure a more operative and complete screening about deleterious genic alterations. My project mainly relates to the genotype-phenotype correlation, with possible functional studies to make clear the pathogenetic role in candidate genes found with different analytic strategies like array-CGH, NGS (Next-Generation Seguencing) and Sanger sequencing. In this regard, we are planning to study the role of MEG3 (maternally expressed gene 3) and MEG8 (maternally expressed gene 8) (14q32.2) in gene activation and embryonic differentiation. These genes encode for imprinted long non-coding RNA. The aim is to induce pluripotent stem cells from controls and patients with CNV in 14q32.2 fibroblasts to differentiate them in different tissues and then study the expression levels. This research could make clear their role in embryogenesis.
