Universitą degli studi di Pavia
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Ferraro research activity
My research aims to study the biological activity of resveratrol and its synthetic analogue, 4-4 'dihydroxy-trans-stilbene, in vitro and in vivo.
After having studied the antiproliferative activity of the synthetic in cancer cells by comparing it with that of the natural compound, I worked to clarify the mechanism of action of 4-4 'dihydroxy-trans-stilbene investigating the protein levels of certain proteins involved in the replication cycle of mammary adenocarcinoma cells (MCF-7). From these investigations, I found that the synthetic analogue exhibits antiproliferative activity higher than the natural compound and a different mechanism of action. Now, the second phase of my project is ongoing and has the purpose to assess the anticancer effects of 4.4'-dihydroxy-trans-stilbene in an experimental animal model consisting of C57 mice inoculated with transplantable tumor cells LLC1 (Lewis Lung carcinoma), previously cultivated in culture.
After having studied the antiproliferative activity of the synthetic in cancer cells by comparing it with that of the natural compound, I worked to clarify the mechanism of action of 4-4 'dihydroxy-trans-stilbene investigating the protein levels of certain proteins involved in the replication cycle of mammary adenocarcinoma cells (MCF-7). From these investigations, I found that the synthetic analogue exhibits antiproliferative activity higher than the natural compound and a different mechanism of action. Now, the second phase of my project is ongoing and has the purpose to assess the anticancer effects of 4.4'-dihydroxy-trans-stilbene in an experimental animal model consisting of C57 mice inoculated with transplantable tumor cells LLC1 (Lewis Lung carcinoma), previously cultivated in culture.
