Università degli studi di Pavia
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Name: Martina
Surname: Uggè
Place and Date of Birth: Milano, june 3d, 1986
Nationality: Italian
Current work address: Istituto di Genetica Molecolare-CNR, Via Abbiategrasso, 207 - 27100 Pavia (Italia)
email: martina.ugge01@universitadipavia.it ; martina.ugge@igm.cnr.it
Cell phone: +393288676794
CURRENT POSITION:
From December, 2013: Fellowship supported by Regione Lombardia at the Italian National Research Council (CNR) of Pavia, as part of the project "Alterarazioni del NER e Neurodegenerazione", directed by Dott.ssa Donata Orioli.
From October, 2013: PhD student in the program "Genetics, Molecular and Cellular Biology" at Università degli Studi di Pavia, cycle XXIX.
ACQUIRED KNOWLEDGE:
2011-2012: Sector of General Pathology and Veterinary Pathological Anatomy, Department of Veterinary Science and Public Health of Università degli Studi di Milano, Italy:
Study of the gene expression of proteins, qualitative and quantitative analysis performed through PCR and Real Time PCR, RNA extraction, retrotranscription, validation of antibody crossreactivity through Western Blotting – Immunostaining, study of the immunohistochemical localization of proteins.
2009: Sector of General Pathology and Veterinary Pathological Anatomy, Department of Veterinary Science and Public Health of Università degli Studi di Milano, Italy:
Purification for in vitro utilization of proteins from human serum. HPLC, Western Blotting – Immunostaining, protein quantification through spectophotometrical techniques, purity analysis through Limulus Amebocyte Lysate (LAL) Test for the detection and quantification of bacterial endotoxins.
EDUCATION:
February, 2013: MSc Molecular Biology and Genetics, Faculty of Science, Università degli Studi di Pavia, Italy, graduated with full marks and honors (110 cum laude). Experimental thesis title: “ Gene expression and immunohistochemical localization of adiponectin and adiponectin receptors 1 and 2 in bovine mammary gland”.
Coordinator: Prof. Elena Giulotto; advisor: Dott. Fabrizio Ceciliani.
Thesis realized at the Sector of General Pathology and Veterinary Pathological Anatomy, Department of Veterinary Science and Public Health of Università degli Studi di Milano, Italy.
February, 2010: BSc Veterinary Biotechnology, Faculty of Veterinary Medicine, Università degli Studi di Milano, Italy, graduated 104/110. Experimental thesis title: “Purification for in-vitro utilization of the alpha1-acid glycoprotein”.
Coordinator: Dott. Fabrizio Ceciliani.
Thesis realized at the Sector of General Pathology and Veterinary Pathological Anatomy, Department of Veterinary Science and Public Health of Università degli Studi di Milano, Italy.
July, 2005: High school Diploma in Languages, Liceo Europeo Orsoline di San Carlo, Como, Italy, graduated 90/100.
RESEARCH ACTIVITY:
December 2013 -at present. Laboratory of Human Genetics and Genomics, Institute of Molecular Genetics – National Research Council, Pavia-Italy.
Research Project
Nucleotide excision repair (NER) is a DNA repair system that removes a variety of DNA lesions, including ultraviolet-induced damages, through the removal of the oligonucleotide containing the lesion. Transcription-coupled NER (TC-NER) efficiently removes lesions from the transcribed strands of active genes. Various hereditary diseases involve defects in NER, including Cockayne Syndrome (CS), a rare autosomal recessive disorder due to mutations in CS genes.
CS patients exhibit diverse clinical symptoms such as growth failure, neurological dysfunctions, mental retardation, photosensitivity of the skin and hypersensitivity to UV light.
The research activity is focused on the identification of new CSA protein interactants involved in oxidative damage removal and in the molecular mechanisms which may be responsible for neurodegenration in CS patients. Therefore, the interaction between CSA and other proteins implicated in neurodegenerative diseases will be analyzed, with a particular focus on Alzheimer's and Parkinson's Disease.
Publications
Lecchi C, Giudice C, Uggè M, Scarafoni A, Baldi A, Sartorelli P. Characterisation of adiponectin and its receptors in the bovine mammary gland and in milk. Vet J. 2015 Jan 14. pii: S1090-0233(15)00027-1. doi: 10.1016/j.tvjl.2015.01.009.
PMID: 25676879
Name: Martina
Surname: Uggè
Place and Date of Birth: Milano, june 3d, 1986
Nationality: Italian
Current work address: Istituto di Genetica Molecolare-CNR, Via Abbiategrasso, 207 - 27100 Pavia (Italia)
email: martina.ugge01@universitadipavia.it ; martina.ugge@igm.cnr.it
Cell phone: +393288676794
CURRENT POSITION:
From December, 2013: Fellowship supported by Regione Lombardia at the Italian National Research Council (CNR) of Pavia, as part of the project "Alterarazioni del NER e Neurodegenerazione", directed by Dott.ssa Donata Orioli.
From October, 2013: PhD student in the program "Genetics, Molecular and Cellular Biology" at Università degli Studi di Pavia, cycle XXIX.
ACQUIRED KNOWLEDGE:
2011-2012: Sector of General Pathology and Veterinary Pathological Anatomy, Department of Veterinary Science and Public Health of Università degli Studi di Milano, Italy:
Study of the gene expression of proteins, qualitative and quantitative analysis performed through PCR and Real Time PCR, RNA extraction, retrotranscription, validation of antibody crossreactivity through Western Blotting – Immunostaining, study of the immunohistochemical localization of proteins.
2009: Sector of General Pathology and Veterinary Pathological Anatomy, Department of Veterinary Science and Public Health of Università degli Studi di Milano, Italy:
Purification for in vitro utilization of proteins from human serum. HPLC, Western Blotting – Immunostaining, protein quantification through spectophotometrical techniques, purity analysis through Limulus Amebocyte Lysate (LAL) Test for the detection and quantification of bacterial endotoxins.
EDUCATION:
February, 2013: MSc Molecular Biology and Genetics, Faculty of Science, Università degli Studi di Pavia, Italy, graduated with full marks and honors (110 cum laude). Experimental thesis title: “ Gene expression and immunohistochemical localization of adiponectin and adiponectin receptors 1 and 2 in bovine mammary gland”.
Coordinator: Prof. Elena Giulotto; advisor: Dott. Fabrizio Ceciliani.
Thesis realized at the Sector of General Pathology and Veterinary Pathological Anatomy, Department of Veterinary Science and Public Health of Università degli Studi di Milano, Italy.
February, 2010: BSc Veterinary Biotechnology, Faculty of Veterinary Medicine, Università degli Studi di Milano, Italy, graduated 104/110. Experimental thesis title: “Purification for in-vitro utilization of the alpha1-acid glycoprotein”.
Coordinator: Dott. Fabrizio Ceciliani.
Thesis realized at the Sector of General Pathology and Veterinary Pathological Anatomy, Department of Veterinary Science and Public Health of Università degli Studi di Milano, Italy.
July, 2005: High school Diploma in Languages, Liceo Europeo Orsoline di San Carlo, Como, Italy, graduated 90/100.
RESEARCH ACTIVITY:
December 2013 -at present. Laboratory of Human Genetics and Genomics, Institute of Molecular Genetics – National Research Council, Pavia-Italy.
Research Project
Nucleotide excision repair (NER) is a DNA repair system that removes a variety of DNA lesions, including ultraviolet-induced damages, through the removal of the oligonucleotide containing the lesion. Transcription-coupled NER (TC-NER) efficiently removes lesions from the transcribed strands of active genes. Various hereditary diseases involve defects in NER, including Cockayne Syndrome (CS), a rare autosomal recessive disorder due to mutations in CS genes.
CS patients exhibit diverse clinical symptoms such as growth failure, neurological dysfunctions, mental retardation, photosensitivity of the skin and hypersensitivity to UV light.
The research activity is focused on the identification of new CSA protein interactants involved in oxidative damage removal and in the molecular mechanisms which may be responsible for neurodegenration in CS patients. Therefore, the interaction between CSA and other proteins implicated in neurodegenerative diseases will be analyzed, with a particular focus on Alzheimer's and Parkinson's Disease.
Publications
Lecchi C, Giudice C, Uggè M, Scarafoni A, Baldi A, Sartorelli P. Characterisation of adiponectin and its receptors in the bovine mammary gland and in milk. Vet J. 2015 Jan 14. pii: S1090-0233(15)00027-1. doi: 10.1016/j.tvjl.2015.01.009.
PMID: 25676879
