Universitą degli studi di Pavia
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Spadaro's curriculum
Curriculum
Name: Francesca
Surname: Spadaro
EDUCATION
2012 Master Degree in Molecular Biology of the Cell. University of Milan, Italy. Final grade: 110/110.
Thesis title: “MECCANISMI DI SPEGNIMENTO DEL POST REPLICATION REPAIR IN SACCHAROMYCES CEREVISIAE DOPO DANNO DA UV”
Supervisor: Prof. Marco Muzi-Falconi
Co-supervisor: Dott. Flavio Amara
2008 First Degree in Natural Sciences. University of Milan, Italy. Final grade: 101/110.
Thesis title: “MODALITA' DI DECOMPOSIZIONE E COMPORTAMENTO DELLA ENTOMOFAUNA NECROFILA IN SEGUITO A 'BRUCIATURA' DI CARCASSE: STUDIO SPERIMENTALE SU MODELLO ANIMALE IN PERIODO INVERNALE”
Supervisor: Prof. Cristina Cattaneo
Co-supervisor: Dott. Davide Porta
LANGUAGES:
English
Italian
COMPUTER SKILLS
Thorough knowledge of Windows, Mac and Linux operating systems.
Research project
A very promising drug against Burkholderia cenocepacia
Burkholderia cenocepacia is considered one of the most serious pathogens in CF patients and it causes infections in about 3.5% of them. B. cenocepacia is highly resistant to antibiotics, thus prompting the need for new strategies for the control of infections. In this project we will pursue three aims: 1) Heterologous production of RND-4 transporter for future structural studies and drug design in order to find molecules that will block this pump; 2) Synthesis of new compounds against B. cenocepacia. We recently found that a pyridine compound is very active and we identified a mechanism of resistance, which relies on the extrusion of the new drug by RND-4 transporter. We aim to synthetize new derivatives that will not be recognized by the pump as a substrate; 3) Target identification of pyridine derivatives through selection and genome sequencing of spontaneous resistant mutants.
Publications
ABSTRACTS FOR POSTERS:
F. Amara, R. Colombo, F. Spadaro, D. Besozzi, M. Muzi-Falconi, P. Plevani.
PCNA ubiquitylation as the wet readout of a Post-Replication Repair computational model.
Ubiquitin and ubiquitin-like modifiers: from functional modules to Systems Biology, Cavtat (Dubrovnik), Croatia, September 21-25, 2011.
Name: Francesca
Surname: Spadaro
EDUCATION
2012 Master Degree in Molecular Biology of the Cell. University of Milan, Italy. Final grade: 110/110.
Thesis title: “MECCANISMI DI SPEGNIMENTO DEL POST REPLICATION REPAIR IN SACCHAROMYCES CEREVISIAE DOPO DANNO DA UV”
Supervisor: Prof. Marco Muzi-Falconi
Co-supervisor: Dott. Flavio Amara
2008 First Degree in Natural Sciences. University of Milan, Italy. Final grade: 101/110.
Thesis title: “MODALITA' DI DECOMPOSIZIONE E COMPORTAMENTO DELLA ENTOMOFAUNA NECROFILA IN SEGUITO A 'BRUCIATURA' DI CARCASSE: STUDIO SPERIMENTALE SU MODELLO ANIMALE IN PERIODO INVERNALE”
Supervisor: Prof. Cristina Cattaneo
Co-supervisor: Dott. Davide Porta
LANGUAGES:
English
Italian
COMPUTER SKILLS
Thorough knowledge of Windows, Mac and Linux operating systems.
Research project
A very promising drug against Burkholderia cenocepacia
Burkholderia cenocepacia is considered one of the most serious pathogens in CF patients and it causes infections in about 3.5% of them. B. cenocepacia is highly resistant to antibiotics, thus prompting the need for new strategies for the control of infections. In this project we will pursue three aims: 1) Heterologous production of RND-4 transporter for future structural studies and drug design in order to find molecules that will block this pump; 2) Synthesis of new compounds against B. cenocepacia. We recently found that a pyridine compound is very active and we identified a mechanism of resistance, which relies on the extrusion of the new drug by RND-4 transporter. We aim to synthetize new derivatives that will not be recognized by the pump as a substrate; 3) Target identification of pyridine derivatives through selection and genome sequencing of spontaneous resistant mutants.
Publications
ABSTRACTS FOR POSTERS:
F. Amara, R. Colombo, F. Spadaro, D. Besozzi, M. Muzi-Falconi, P. Plevani.
PCNA ubiquitylation as the wet readout of a Post-Replication Repair computational model.
Ubiquitin and ubiquitin-like modifiers: from functional modules to Systems Biology, Cavtat (Dubrovnik), Croatia, September 21-25, 2011.
