Università degli studi di Pavia
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Tedaldi's curriculum
Curriculum
Date and place of birth: 09/03/1986 - Forlì (Italy)
Current address: via Roma 68, Meldola (FC)
Nationality: Italian
Email: gianluca.tedaldi01@universitadipavia.it
Laboratory experience
From 01/09/2015 - present
Researcher at “Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori” - Meldola (Italy).
Main activities: Study on hereditary tumours through molecular biology techniques such as Next-Generation Sequencing on Illumina platforms, automated direct sequencing, MLPA analysis for the detection of genetic rearrangements.
Area: Epigenomics, risk factors and genetic predisposition – Genetic Counselling
From 01/07/2011 to 31/08/2015
Research collaborator at “Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori” - Meldola (Italy).
Main activities: Collaboration to the projects “Identification of the molecular profile in male breast cancer” (2011-2012), “Search for new molecular markers for hereditary risk: improving the predictability of known genetic profiles and definition of new hereditary risk profiles” (2013-2014) and “ldentification of new molecular factors involved in cancer development in patients with con suspected hereditary predisposition to cancer” (2015).
Area: Diagnostics - Genetic Counselling
From 12/2010 to 06/2011
Voluntary internship at “Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori” - Meldola (Italy).
Main activities: Study on hereditary tumours through molecular biology techniques.
Area: Diagnostics - Genetic Counselling
From 01/2010 to 12/2010
Internship for Master’s Degree at “Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori” - Meldola (Italy).
Main activities: Study on hereditary tumours through molecular biology techniques, completed with the writing of the thesis “Caratterizzazione molecolare di tumori gastrici con sospetta predisposizione ereditaria: l’esperienza di Area Vasta Romagna”.
Area: Diagnostics - Genetic Counselling
From 06/2008 to 09/2008
Internship for Bachelor’s Degree at “Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori” - Meldola (Italy).
Main activities: Study on hereditary tumours through molecular biology techniques, completed with the writing of the thesis “Il tumore della mammella maschile di origine ereditaria: l’esperienza di un’area del centro-nord d’Italia”.
Area: Diagnostics - Genetic Counselling
Education
From October 2015 – in progress
PhD Program in Genetics, Molecular and Cellular Biology
University of Pavia
06/2011
Qualification as Biologist (section A)
Carlo Bo University - Urbino
From 2008 to 2010
Master's degree in Molecular and Cellular Biology
Alma Mater Studiorum - Bologna
Final mark: 110/110 cum laude
From 2005 to 2008
Bachelor’s Degree in Biological Sciences
Alma Mater Studiorum - Bologna
Final mark: 104/110
From 2000 to 2005
High school diploma
Liceo Classico G.B.Morgagni - Forlì
Final mark: 100/100
Languages
Italian: native
English: intermediate (B2 level - PET and FIRST certificates)
French: basic
Professional skills
DNA, RNA and protein extraction from different kinds of biological samples. Knowledge of DNA amplification techniques (PCR and qPCR), DNA sequencing (Sanger Sequencing and Next-Generation Sequencing) and other molecular biology techniques (MLPA and microsatellite instability analysis). Knowledge of basic techniques for maintenance of in vitro cell cultures.
Informatics and bioinformatics skills
Knowledge of Microsoft and Macintosh operating systems and Office software in particular Word, Excel, PowerPoint and Access. Good skills in web brousing and using biological databases (Genbank, UCSC, Ensembl, PDB, Uniprot, Pubmed, OMIM, GeneCards, dbSNP). Excellent skills in using softwares for biomolecular analysis (Miseq Reporter, Sequencing Analysis, Coffalyser, Genemapper, VariantStudio and SureCall).
Pubblicazioni e comunicazioni a congressi
Papers
Gianluca Tedaldi, Francesca Pirini, Michela Tebaldi, Valentina Zampiga, Ilaria Cangini, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Raefa Abou Khouzam, Chiara Molinari, Carla Oliveira, Paolo Morgagni, Luca Saragoni, Maria Bencivenga, Paola Ulivi, Dino Amadori, Giovanni Martinelli, Fabio Falcini, Guglielmina Nadia Ranzani, Daniele Calistri. Multigene panel testing increases the number of loci associated with gastric cancer predisposition. Cancers 2019.
Francesca Pirini, Gianluca Tedaldi, Rita Danesi, Ilaria Cangini, Maria Maddalena Tumedei, Anna Ferrari, Silvia Vitali, Giulia De Maio, Carolina Terragna, Vincenza Solli, Michela Tebaldi, Maurizio Puccetti, Valentina Zampiga, Mila Ravegnani, Paola Ulivi, Fabio Falcini, Giovanni Martinelli, Daniele Calistri. Identification of a novel large EPCAM-MSH2 duplication, concurrently with LOHs in chromosome 20 and X, in a family with Lynch syndrome. A case report. International Journal of Colorectal Disease 2019.
Tania Rossi, Gianluca Tedaldi, Elisabetta Petracci, Raefa Abou Khouzam, Guglielmina Nadia Ranzani, Paolo Morgagni, Luca Saragoni, Manlio Monti, Daniele Calistri, Paola Ulivi, Chiara Molinari. E-cadherin Downregulation and microRNAs in Sporadic Intestinal-Type Gastric Cancer. International Journal of Molecular Sciences 2019.
Piera Rizzolo, Valentina Silvestri, Virginia Valentini, Veronica Zelli, Agostino Bucalo, Ines Zanna, Simonetta Bianchi, Maria Grazia Tibiletti, Antonio Russo, Liliana Varesco, Gianluca Tedaldi, Bernardo Bonanni, Jacopo Azzollini, Siranoush Manoukian, Anna Coppa, Giuseppe Giannini, Laura Cortesi, Alessandra Viel, Marco Montagna, Paolo Peterlongo, Paolo Radice, Domenico Palli, Laura Ottini. Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk. Endocrine Connections 2019.
SM Nielsen, DM Eccles, I Romero, F Al-Mulla, J Balmaña, M Biancolella, R Blok, MA Caligo, M Calvello, GL Capone, P Cavalli, TL Chan, KBM Claes, L Cortesi, FJ Couch, M de la Hoya, S De Toffol, O Diez, S M Domchek, R Eeles, A Efremidis, F Fostira, D Goldgar, M Hadjisavvas, TvOHansen, A Hirasawa, C Houdayer, P Kleiblova, S Krieger, C Lázaro, M Loizidou, S Manoukian, A R Mensenkamp, S Moghadasi, A N Monteiro, L Mori, A Morrow, N Naldi, HR Nielsen, OI Olopade, NS Pachter, EI Palmero, IS Pedersen, M Piane, M Puzzo, M Robson, M Rossing, MC Sini, A Solano, J Soukupova, Gianluca Tedaldi, M Teixeira, M Thomassen, MG Tibiletti, A Toland, T Törngren, E Vaccari, L Varesco, A Vega, Y Wallis, B Wappenschmidt, J Weitzel, A B Spurdle, A De Nicolo, EB Gómez-García. Genetic Testing and Clinical Management Practices for Variants in Non-BRCA1/2 Breast (and Breast and Ovarian) Cancer Susceptibility Genes: an International Survey by the ENIGMA Clinical Working Group. JCO Precision Oncology 2018.
Marco Cassone, Leila Baghernajad Salehi, Gianluca Tedaldi, Michela Tebaldi, Valentina Zampiga, Michela Biancolella, Barbara Testa, Daniele Calistri, Gerarda Mastrogiorgio, Silvia Lanciotti, Maria Rosaria D'Apice, Giuseppe Novelli, Federica Sangiuolo. Coexistence of Two Novel Mutations in CDKN2A and PMS1 Genes in a Single Patient Identifies a New and Severe Cancer Predisposition Syndrome. Oncomedicine 2017.
Gianluca Tedaldi, Michela Tebaldi, Valentina Zampiga, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Ilaria Cangini, Francesca Pirini, Elisabetta Petracci, Andrea Rocca, Fabio Falcini, Dino Amadori, Daniele Calistri. Multiple-gene panel analysis in a case series of 255 women with hereditary breast and ovarian cancer. Oncotarget 2017.
Samanta Salvi, Giorgia Gurioli, Ugo De Giorgi, Vincenza Conteduca, Gianluca Tedaldi, Daniele Calistri, Valentina Casadio. Cell-free DNA as a diagnostic marker for cancer: current insights. OncoTargets and Therapy 2016.
Valentina Zampiga, Rita Danesi, Gianluca Tedaldi, Michela Tebaldi, Ilaria Cangini, Francesca Pirini, Cristina Pittureri, Elena Amaducci, Luciano Guidi, Marina Faedi, Dino Amadori, Fabio Falcini, Daniele Calistri. Multiple primary tumours in a family with Li-Fraumeni syndrome with a TP53 germline mutation identified by Next-Generation Sequencing. The International Journal of Biological Markers 2016.
Laura Bonanno, Fiorella Calabrese, Giorgia Nardo, Daniele Calistri, Michela Tebaldi, Gianluca Tedaldi, Valentina Polo, Stefania Vuljan, Adolfo Favaretto, PierFranco Conte, Alberto Amadoria, Federico Rea, Stefano Indraccolo. Morphological and genetic heterogeneity in multifocal lung adenocarcinoma: The case of a never-smoker woman. Lung Cancer 2016.
Chiara Arienti, Michele Zanoni, Sara Pignatta, Alberto Del Rio, Silvia Carloni, Michela Tebaldi, Gianluca Tedaldi, Anna Tesei. Preclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer. Oncotarget 2016.
Gianluca Tedaldi, Rita Danesi, Valentina Zampiga, Michela Tebaldi, Lucia Bedei, Wainer Zoli, Dino Amadori, Fabio Falcini, Daniele Calistri. First evidence of a large CHEK2 duplication involved in cancer predisposition in an Italian family with hereditary breast cancer. BMC Cancer 2014.
Abstracts
Gianluca Tedaldi, Francesca Pirini, Michela Tebaldi, Valentina Zampiga, Ilaria Cangini, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Raefa Abou Khouzam, Chiara Molinari, Paolo Morgagni, Luca Saragoni, Paola Ulivi, Dino Amadori, Giovanni Martinelli, Fabio Falcini, Guglielmina Nadia Ranzani, Daniele Calistri. Multigene panel testing increases the number of loci associated with gastric cancer predisposition at the 13th International Gastric Cancer Congress (Prague-Czech Republic, 8th-11th May 2019).
Chiara Molinari, Laura Capelli, Paolo Morgagni, Paola ulivi, Sara Ravaioli, Maria Maddalena Tumedei, Gianluca Tedaldi, Raefa Abou khouzam, Emanuela Scarpi, Daniele Calistri, Massimiliano Bonafé, A. Tomezzoli, C. Castelli, M.R. Ambrosio, A.D’Ignazio, Luca Saragoni. Early Gastric Cancer: identification of molecular markers able to distinguish penetrating lesions with different prognosis at the 13th International Gastric Cancer Congress (Prague-Czech Republic, 8th-11th May 2019).
Valentina Zampiga, Ilaria Cangini, Rita Danesi, Valentina Arcangeli, Gianluca Tedaldi, Michela Tebaldi, Francesca Pirini, Mila Ravegnani, Fabio Falcini, Massimiliano Bonafè, Daniele Calistri. Hereditary breast and ovarian cancer in Oncology Network of Area Vasta Romagna (AVR) at the 3rd Annual Meeting ACC 2018 organized by Alleanza Contro il Cancro at the Ospedale San Raffaele (Milan-Italy, 29th-31st October 2018).
Gianluca Tedaldi, Francesca Pirini, Michela Tebaldi, Valentina Zampiga, Ilaria Cangini, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Raefa Abou Khouzam, Chiara Molinari, Massimiliano Bonafé, Dino Amadori, Giovanni Martinelli, Fabio Falcini, Guglielmina Nadia Ranzani, Daniele Calistri. Multigene panel testing increases the number of loci associated with gastric cancer predisposition at the XXI SIGU National Congress (Catania-Italy, 25th-27th October 2018).
Gianluca Tedaldi, Francesca Pirini, Valentina Zampiga, Ilaria Cangini, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Raefa Abou Khouzam, Chiara Molinari, Patricia Oliveira, Joana Carvalho, Anabela Ferro, Sara Teles, Paolo Morgagni, Luca Saragoni, Massimiliano Bonafé, Dino Amadori, Giovanni Martinelli, Fabio Falcini, Carla Oliveira, Guglielmina Nadia Ranzani, Daniele Calistri. Hereditary Diffuse Gastric Cancer at the congress “The new frontiers in Gastric Cancer diagnosis and treatment” (Forlì-Italy, 13th-14th September 2018).
Gianluca Tedaldi, Valentina Zampiga, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Ilaria Cangini, Francesca Pirini, Massimiliano Bonafè, Giorgio Ercolani, Paolo Morgagni, Luca Saragoni, Giovanni Martinelli, Fabio Falcini, Daniele Calistri. La genetica: alla ricerca di una causa che coinvolge un’intera famiglia at the exhibition "Un territorio, un problema, la storia di una sfida" (Forlì-Italy, 10th-15th September 2018).
Chiara Molinari, Tania Rossi, Raefa Abou Khouzam, Guglielmina Nadia Ranzani, Gianluca Tedaldi, Paola Ulivi, Paolo Morgagni, Luca Saragoni, Manlio Monti, Daniele Calistri. MicroRNAs and CDH1 regulation in intestinal-type gastric cancer at the ESMO World Congress on Gastrointestinal Cancer 2018 (Barcelona-Spain, 20th-23rd June 2018).
Gianluca Tedaldi, Valentina Zampiga, Michela Tebaldi, Chiara Molinari, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Ilaria Cangini, Francesca Pirini, Guglielmina Nadia Ranzani, Raefa Abou Khouzam, Fabio Falcini, Dino Amadori, Daniele Calistri. Familial Gastric Cancer: Results of a Multiple-Gene Sequencing Panel for Cancer Risk Assessment at the 2nd Annual Meeting ACC 2017 organized by Alleanza Contro il Cancro at the Ospedale Pediatrico Bambino Gesù (Rome-Italy, 3rd-5th October 2017).
Gianluca Tedaldi, Valentina Zampiga, Rita Danesi, Michela Tebaldi, Valentina Arcangeli, Mila Ravegnani, Dino Amadori, Fabio Falcini, Daniele Calistri. Next-Generation Sequencing in clinical practice: application of a multigene panel in a case series with Hereditary Breast and Ovarian Cancer syndrome at the congress “Hereditary Breast and Ovarian Cancers” at the Istituto Tumori di Bari (Bari-Italy, 25th-27th March 2015).
Gianluca Tedaldi, Rita Danesi, Valentina Zampiga, Michela Tebaldi, Valentina Arcangeli, Mila Ravegnani, Dino Amadori, Fabio Falcini, Daniele Calistri. Genetic factors other than CDH1 involved in the predisposition to gastric cancer: the experience of Area Vasta Romagna at the 10th International Gastric Cancer Congress (Verona-Italy,19th-22nd June 2013).
Valentina Zampiga, Rita Danesi, Gianluca Tedaldi, Lucia Bedei, Fabio Falcini, Wainer Zoli, Dino Amadori, Daniele Calistri. Genetic alterations in male breast cancer: the experience of a north-central region of Italy at the 2nd Annual Joint Meeting (Bari/NYU) Hereditary Breast & Ovarian Cancer (New York-USA, 14th-17th September 2011).
Oral communications
“Multiple-gene panel analysis in an Italian cohort of patients with familial gastric cancer” at the Insight congress 2019 (Auckland-New Zealand, 20th-23rd March 2019).
“Multiple-gene panel analysis in an Italian cohort of patients with familial gastric cancer” at the XV AIFEG congress (Catania-Italy, 26th-27th October 2018).
“Familial Gastric Cancer & Next-Generation Sequencing: results from a panel of 94 genes in an Italian case series” at the Insight congress 2017 (Florence-Italy, 5th-8th July 2017).
“Cancro gastrico familiare: Quali test richiedere al biologo molecolare?” during the seminar “Tavola Rotonda su Familiarità e Carcinoma Gastrico” at CEUB (Bertinoro-Italy, 10th February 2017).
“DNA e mutazioni” during the seminar “La Biologia Molecolare nell’Oncologia Clinica” at CEUB (Bertinoro-Italy, 27th-28th October 2016).
“Identificazione di nuove alterazioni correlate col rischio ereditario tramite sistemi NGS” during the seminar ”Next or Now Generation Sequencing? Le attuali applicazioni nella diagnostica dei tumori ematologici, solidi ed ereditari” at the Istituto Europeo di Oncologia (Milan-Italy, 21st September 2016).
“Percorso per l’identificazione e il monitoraggio di pazienti con storia personale o familiare di tumore gastrico” at the meeting of SICO-GIRCG oncoteam (Pontignano-Italy, 8th April 2016).
“Familial gastric cancer & Next-Generation Sequencing: results from a panel of 94 genes in an Italian case series” at the 11th International Gastric Cancer Congress (São Paulo-Brazil, 4th-6th June 2015).
“Applicazione di un protocollo di arricchimento NGS in diagnostica molecolare” during the seminar “Nuovi approcci genetici nella diagnostica molecolare” at IRST (Meldola-Italy, 24th November 2014).
Research project
New genetic factors in the development of familial and sporadic gastric cancer
The onset of gastric cancer is determined by several factors, many of which are still unknown, but it is estimated that about 5-10% of cases are the result of a genetic predisposition. The main known gene involved in inherited forms of gastric cancer is CDH1, encoding the membrane protein E-cadherin, which plays a key role in the formation of cell-cell junctions and in signal transduction pathways regulating cell survival and differentiation. To date about one hundred mutations in the CDH1 gene have been identified. These mutations are not only responsible for the onset of gastric cancer, but also of other cancers, such as breast and colorectal cancers.
This gene is not the only cause of susceptibility to gastric cancer and it is known that many other factors can contribute to determine the risk of developing these cancers.
The first aim of the study is the analysis of mutation of the CDH1 gene in a group of patients with high familiarity for gastric cancer in order to assess the presence of predisposing genetic alterations.
However, since many of these tumors are not correlated with germline mutations in CDH1 gene, the second aim of our study is to identify new risk factors for gastric cancer development in individuals with high familiarity for this disease.
Therefore, we will search for alterations in other genes involved in oncogenesis using Next-Generation Sequencing (NGS) technologies, comparing a group of patients with high family history of gastric cancer with a group of patients without a family history of this cancer. On the genetic variants identified we will perform an assessment of pathogenicity through bioinformatic analysis, segregation analysis, functional tests and research of these variants in healthy controls from the same population.
Date and place of birth: 09/03/1986 - Forlì (Italy)
Current address: via Roma 68, Meldola (FC)
Nationality: Italian
Email: gianluca.tedaldi01@universitadipavia.it
Laboratory experience
From 01/09/2015 - present
Researcher at “Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori” - Meldola (Italy).
Main activities: Study on hereditary tumours through molecular biology techniques such as Next-Generation Sequencing on Illumina platforms, automated direct sequencing, MLPA analysis for the detection of genetic rearrangements.
Area: Epigenomics, risk factors and genetic predisposition – Genetic Counselling
From 01/07/2011 to 31/08/2015
Research collaborator at “Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori” - Meldola (Italy).
Main activities: Collaboration to the projects “Identification of the molecular profile in male breast cancer” (2011-2012), “Search for new molecular markers for hereditary risk: improving the predictability of known genetic profiles and definition of new hereditary risk profiles” (2013-2014) and “ldentification of new molecular factors involved in cancer development in patients with con suspected hereditary predisposition to cancer” (2015).
Area: Diagnostics - Genetic Counselling
From 12/2010 to 06/2011
Voluntary internship at “Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori” - Meldola (Italy).
Main activities: Study on hereditary tumours through molecular biology techniques.
Area: Diagnostics - Genetic Counselling
From 01/2010 to 12/2010
Internship for Master’s Degree at “Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori” - Meldola (Italy).
Main activities: Study on hereditary tumours through molecular biology techniques, completed with the writing of the thesis “Caratterizzazione molecolare di tumori gastrici con sospetta predisposizione ereditaria: l’esperienza di Area Vasta Romagna”.
Area: Diagnostics - Genetic Counselling
From 06/2008 to 09/2008
Internship for Bachelor’s Degree at “Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori” - Meldola (Italy).
Main activities: Study on hereditary tumours through molecular biology techniques, completed with the writing of the thesis “Il tumore della mammella maschile di origine ereditaria: l’esperienza di un’area del centro-nord d’Italia”.
Area: Diagnostics - Genetic Counselling
Education
From October 2015 – in progress
PhD Program in Genetics, Molecular and Cellular Biology
University of Pavia
06/2011
Qualification as Biologist (section A)
Carlo Bo University - Urbino
From 2008 to 2010
Master's degree in Molecular and Cellular Biology
Alma Mater Studiorum - Bologna
Final mark: 110/110 cum laude
From 2005 to 2008
Bachelor’s Degree in Biological Sciences
Alma Mater Studiorum - Bologna
Final mark: 104/110
From 2000 to 2005
High school diploma
Liceo Classico G.B.Morgagni - Forlì
Final mark: 100/100
Languages
Italian: native
English: intermediate (B2 level - PET and FIRST certificates)
French: basic
Professional skills
DNA, RNA and protein extraction from different kinds of biological samples. Knowledge of DNA amplification techniques (PCR and qPCR), DNA sequencing (Sanger Sequencing and Next-Generation Sequencing) and other molecular biology techniques (MLPA and microsatellite instability analysis). Knowledge of basic techniques for maintenance of in vitro cell cultures.
Informatics and bioinformatics skills
Knowledge of Microsoft and Macintosh operating systems and Office software in particular Word, Excel, PowerPoint and Access. Good skills in web brousing and using biological databases (Genbank, UCSC, Ensembl, PDB, Uniprot, Pubmed, OMIM, GeneCards, dbSNP). Excellent skills in using softwares for biomolecular analysis (Miseq Reporter, Sequencing Analysis, Coffalyser, Genemapper, VariantStudio and SureCall).
Pubblicazioni e comunicazioni a congressi
Papers
Gianluca Tedaldi, Francesca Pirini, Michela Tebaldi, Valentina Zampiga, Ilaria Cangini, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Raefa Abou Khouzam, Chiara Molinari, Carla Oliveira, Paolo Morgagni, Luca Saragoni, Maria Bencivenga, Paola Ulivi, Dino Amadori, Giovanni Martinelli, Fabio Falcini, Guglielmina Nadia Ranzani, Daniele Calistri. Multigene panel testing increases the number of loci associated with gastric cancer predisposition. Cancers 2019.
Francesca Pirini, Gianluca Tedaldi, Rita Danesi, Ilaria Cangini, Maria Maddalena Tumedei, Anna Ferrari, Silvia Vitali, Giulia De Maio, Carolina Terragna, Vincenza Solli, Michela Tebaldi, Maurizio Puccetti, Valentina Zampiga, Mila Ravegnani, Paola Ulivi, Fabio Falcini, Giovanni Martinelli, Daniele Calistri. Identification of a novel large EPCAM-MSH2 duplication, concurrently with LOHs in chromosome 20 and X, in a family with Lynch syndrome. A case report. International Journal of Colorectal Disease 2019.
Tania Rossi, Gianluca Tedaldi, Elisabetta Petracci, Raefa Abou Khouzam, Guglielmina Nadia Ranzani, Paolo Morgagni, Luca Saragoni, Manlio Monti, Daniele Calistri, Paola Ulivi, Chiara Molinari. E-cadherin Downregulation and microRNAs in Sporadic Intestinal-Type Gastric Cancer. International Journal of Molecular Sciences 2019.
Piera Rizzolo, Valentina Silvestri, Virginia Valentini, Veronica Zelli, Agostino Bucalo, Ines Zanna, Simonetta Bianchi, Maria Grazia Tibiletti, Antonio Russo, Liliana Varesco, Gianluca Tedaldi, Bernardo Bonanni, Jacopo Azzollini, Siranoush Manoukian, Anna Coppa, Giuseppe Giannini, Laura Cortesi, Alessandra Viel, Marco Montagna, Paolo Peterlongo, Paolo Radice, Domenico Palli, Laura Ottini. Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk. Endocrine Connections 2019.
SM Nielsen, DM Eccles, I Romero, F Al-Mulla, J Balmaña, M Biancolella, R Blok, MA Caligo, M Calvello, GL Capone, P Cavalli, TL Chan, KBM Claes, L Cortesi, FJ Couch, M de la Hoya, S De Toffol, O Diez, S M Domchek, R Eeles, A Efremidis, F Fostira, D Goldgar, M Hadjisavvas, TvOHansen, A Hirasawa, C Houdayer, P Kleiblova, S Krieger, C Lázaro, M Loizidou, S Manoukian, A R Mensenkamp, S Moghadasi, A N Monteiro, L Mori, A Morrow, N Naldi, HR Nielsen, OI Olopade, NS Pachter, EI Palmero, IS Pedersen, M Piane, M Puzzo, M Robson, M Rossing, MC Sini, A Solano, J Soukupova, Gianluca Tedaldi, M Teixeira, M Thomassen, MG Tibiletti, A Toland, T Törngren, E Vaccari, L Varesco, A Vega, Y Wallis, B Wappenschmidt, J Weitzel, A B Spurdle, A De Nicolo, EB Gómez-García. Genetic Testing and Clinical Management Practices for Variants in Non-BRCA1/2 Breast (and Breast and Ovarian) Cancer Susceptibility Genes: an International Survey by the ENIGMA Clinical Working Group. JCO Precision Oncology 2018.
Marco Cassone, Leila Baghernajad Salehi, Gianluca Tedaldi, Michela Tebaldi, Valentina Zampiga, Michela Biancolella, Barbara Testa, Daniele Calistri, Gerarda Mastrogiorgio, Silvia Lanciotti, Maria Rosaria D'Apice, Giuseppe Novelli, Federica Sangiuolo. Coexistence of Two Novel Mutations in CDKN2A and PMS1 Genes in a Single Patient Identifies a New and Severe Cancer Predisposition Syndrome. Oncomedicine 2017.
Gianluca Tedaldi, Michela Tebaldi, Valentina Zampiga, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Ilaria Cangini, Francesca Pirini, Elisabetta Petracci, Andrea Rocca, Fabio Falcini, Dino Amadori, Daniele Calistri. Multiple-gene panel analysis in a case series of 255 women with hereditary breast and ovarian cancer. Oncotarget 2017.
Samanta Salvi, Giorgia Gurioli, Ugo De Giorgi, Vincenza Conteduca, Gianluca Tedaldi, Daniele Calistri, Valentina Casadio. Cell-free DNA as a diagnostic marker for cancer: current insights. OncoTargets and Therapy 2016.
Valentina Zampiga, Rita Danesi, Gianluca Tedaldi, Michela Tebaldi, Ilaria Cangini, Francesca Pirini, Cristina Pittureri, Elena Amaducci, Luciano Guidi, Marina Faedi, Dino Amadori, Fabio Falcini, Daniele Calistri. Multiple primary tumours in a family with Li-Fraumeni syndrome with a TP53 germline mutation identified by Next-Generation Sequencing. The International Journal of Biological Markers 2016.
Laura Bonanno, Fiorella Calabrese, Giorgia Nardo, Daniele Calistri, Michela Tebaldi, Gianluca Tedaldi, Valentina Polo, Stefania Vuljan, Adolfo Favaretto, PierFranco Conte, Alberto Amadoria, Federico Rea, Stefano Indraccolo. Morphological and genetic heterogeneity in multifocal lung adenocarcinoma: The case of a never-smoker woman. Lung Cancer 2016.
Chiara Arienti, Michele Zanoni, Sara Pignatta, Alberto Del Rio, Silvia Carloni, Michela Tebaldi, Gianluca Tedaldi, Anna Tesei. Preclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer. Oncotarget 2016.
Gianluca Tedaldi, Rita Danesi, Valentina Zampiga, Michela Tebaldi, Lucia Bedei, Wainer Zoli, Dino Amadori, Fabio Falcini, Daniele Calistri. First evidence of a large CHEK2 duplication involved in cancer predisposition in an Italian family with hereditary breast cancer. BMC Cancer 2014.
Abstracts
Gianluca Tedaldi, Francesca Pirini, Michela Tebaldi, Valentina Zampiga, Ilaria Cangini, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Raefa Abou Khouzam, Chiara Molinari, Paolo Morgagni, Luca Saragoni, Paola Ulivi, Dino Amadori, Giovanni Martinelli, Fabio Falcini, Guglielmina Nadia Ranzani, Daniele Calistri. Multigene panel testing increases the number of loci associated with gastric cancer predisposition at the 13th International Gastric Cancer Congress (Prague-Czech Republic, 8th-11th May 2019).
Chiara Molinari, Laura Capelli, Paolo Morgagni, Paola ulivi, Sara Ravaioli, Maria Maddalena Tumedei, Gianluca Tedaldi, Raefa Abou khouzam, Emanuela Scarpi, Daniele Calistri, Massimiliano Bonafé, A. Tomezzoli, C. Castelli, M.R. Ambrosio, A.D’Ignazio, Luca Saragoni. Early Gastric Cancer: identification of molecular markers able to distinguish penetrating lesions with different prognosis at the 13th International Gastric Cancer Congress (Prague-Czech Republic, 8th-11th May 2019).
Valentina Zampiga, Ilaria Cangini, Rita Danesi, Valentina Arcangeli, Gianluca Tedaldi, Michela Tebaldi, Francesca Pirini, Mila Ravegnani, Fabio Falcini, Massimiliano Bonafè, Daniele Calistri. Hereditary breast and ovarian cancer in Oncology Network of Area Vasta Romagna (AVR) at the 3rd Annual Meeting ACC 2018 organized by Alleanza Contro il Cancro at the Ospedale San Raffaele (Milan-Italy, 29th-31st October 2018).
Gianluca Tedaldi, Francesca Pirini, Michela Tebaldi, Valentina Zampiga, Ilaria Cangini, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Raefa Abou Khouzam, Chiara Molinari, Massimiliano Bonafé, Dino Amadori, Giovanni Martinelli, Fabio Falcini, Guglielmina Nadia Ranzani, Daniele Calistri. Multigene panel testing increases the number of loci associated with gastric cancer predisposition at the XXI SIGU National Congress (Catania-Italy, 25th-27th October 2018).
Gianluca Tedaldi, Francesca Pirini, Valentina Zampiga, Ilaria Cangini, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Raefa Abou Khouzam, Chiara Molinari, Patricia Oliveira, Joana Carvalho, Anabela Ferro, Sara Teles, Paolo Morgagni, Luca Saragoni, Massimiliano Bonafé, Dino Amadori, Giovanni Martinelli, Fabio Falcini, Carla Oliveira, Guglielmina Nadia Ranzani, Daniele Calistri. Hereditary Diffuse Gastric Cancer at the congress “The new frontiers in Gastric Cancer diagnosis and treatment” (Forlì-Italy, 13th-14th September 2018).
Gianluca Tedaldi, Valentina Zampiga, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Ilaria Cangini, Francesca Pirini, Massimiliano Bonafè, Giorgio Ercolani, Paolo Morgagni, Luca Saragoni, Giovanni Martinelli, Fabio Falcini, Daniele Calistri. La genetica: alla ricerca di una causa che coinvolge un’intera famiglia at the exhibition "Un territorio, un problema, la storia di una sfida" (Forlì-Italy, 10th-15th September 2018).
Chiara Molinari, Tania Rossi, Raefa Abou Khouzam, Guglielmina Nadia Ranzani, Gianluca Tedaldi, Paola Ulivi, Paolo Morgagni, Luca Saragoni, Manlio Monti, Daniele Calistri. MicroRNAs and CDH1 regulation in intestinal-type gastric cancer at the ESMO World Congress on Gastrointestinal Cancer 2018 (Barcelona-Spain, 20th-23rd June 2018).
Gianluca Tedaldi, Valentina Zampiga, Michela Tebaldi, Chiara Molinari, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Ilaria Cangini, Francesca Pirini, Guglielmina Nadia Ranzani, Raefa Abou Khouzam, Fabio Falcini, Dino Amadori, Daniele Calistri. Familial Gastric Cancer: Results of a Multiple-Gene Sequencing Panel for Cancer Risk Assessment at the 2nd Annual Meeting ACC 2017 organized by Alleanza Contro il Cancro at the Ospedale Pediatrico Bambino Gesù (Rome-Italy, 3rd-5th October 2017).
Gianluca Tedaldi, Valentina Zampiga, Rita Danesi, Michela Tebaldi, Valentina Arcangeli, Mila Ravegnani, Dino Amadori, Fabio Falcini, Daniele Calistri. Next-Generation Sequencing in clinical practice: application of a multigene panel in a case series with Hereditary Breast and Ovarian Cancer syndrome at the congress “Hereditary Breast and Ovarian Cancers” at the Istituto Tumori di Bari (Bari-Italy, 25th-27th March 2015).
Gianluca Tedaldi, Rita Danesi, Valentina Zampiga, Michela Tebaldi, Valentina Arcangeli, Mila Ravegnani, Dino Amadori, Fabio Falcini, Daniele Calistri. Genetic factors other than CDH1 involved in the predisposition to gastric cancer: the experience of Area Vasta Romagna at the 10th International Gastric Cancer Congress (Verona-Italy,19th-22nd June 2013).
Valentina Zampiga, Rita Danesi, Gianluca Tedaldi, Lucia Bedei, Fabio Falcini, Wainer Zoli, Dino Amadori, Daniele Calistri. Genetic alterations in male breast cancer: the experience of a north-central region of Italy at the 2nd Annual Joint Meeting (Bari/NYU) Hereditary Breast & Ovarian Cancer (New York-USA, 14th-17th September 2011).
Oral communications
“Multiple-gene panel analysis in an Italian cohort of patients with familial gastric cancer” at the Insight congress 2019 (Auckland-New Zealand, 20th-23rd March 2019).
“Multiple-gene panel analysis in an Italian cohort of patients with familial gastric cancer” at the XV AIFEG congress (Catania-Italy, 26th-27th October 2018).
“Familial Gastric Cancer & Next-Generation Sequencing: results from a panel of 94 genes in an Italian case series” at the Insight congress 2017 (Florence-Italy, 5th-8th July 2017).
“Cancro gastrico familiare: Quali test richiedere al biologo molecolare?” during the seminar “Tavola Rotonda su Familiarità e Carcinoma Gastrico” at CEUB (Bertinoro-Italy, 10th February 2017).
“DNA e mutazioni” during the seminar “La Biologia Molecolare nell’Oncologia Clinica” at CEUB (Bertinoro-Italy, 27th-28th October 2016).
“Identificazione di nuove alterazioni correlate col rischio ereditario tramite sistemi NGS” during the seminar ”Next or Now Generation Sequencing? Le attuali applicazioni nella diagnostica dei tumori ematologici, solidi ed ereditari” at the Istituto Europeo di Oncologia (Milan-Italy, 21st September 2016).
“Percorso per l’identificazione e il monitoraggio di pazienti con storia personale o familiare di tumore gastrico” at the meeting of SICO-GIRCG oncoteam (Pontignano-Italy, 8th April 2016).
“Familial gastric cancer & Next-Generation Sequencing: results from a panel of 94 genes in an Italian case series” at the 11th International Gastric Cancer Congress (São Paulo-Brazil, 4th-6th June 2015).
“Applicazione di un protocollo di arricchimento NGS in diagnostica molecolare” during the seminar “Nuovi approcci genetici nella diagnostica molecolare” at IRST (Meldola-Italy, 24th November 2014).
Research project
New genetic factors in the development of familial and sporadic gastric cancer
The onset of gastric cancer is determined by several factors, many of which are still unknown, but it is estimated that about 5-10% of cases are the result of a genetic predisposition. The main known gene involved in inherited forms of gastric cancer is CDH1, encoding the membrane protein E-cadherin, which plays a key role in the formation of cell-cell junctions and in signal transduction pathways regulating cell survival and differentiation. To date about one hundred mutations in the CDH1 gene have been identified. These mutations are not only responsible for the onset of gastric cancer, but also of other cancers, such as breast and colorectal cancers.
This gene is not the only cause of susceptibility to gastric cancer and it is known that many other factors can contribute to determine the risk of developing these cancers.
The first aim of the study is the analysis of mutation of the CDH1 gene in a group of patients with high familiarity for gastric cancer in order to assess the presence of predisposing genetic alterations.
However, since many of these tumors are not correlated with germline mutations in CDH1 gene, the second aim of our study is to identify new risk factors for gastric cancer development in individuals with high familiarity for this disease.
Therefore, we will search for alterations in other genes involved in oncogenesis using Next-Generation Sequencing (NGS) technologies, comparing a group of patients with high family history of gastric cancer with a group of patients without a family history of this cancer. On the genetic variants identified we will perform an assessment of pathogenicity through bioinformatic analysis, segregation analysis, functional tests and research of these variants in healthy controls from the same population.
