Universitą degli studi di Pavia
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Novara's CV
Name and Surname: Francesca Novara
Residence: Via Tasso, 48
27100 Pavia
Cell. + 339 1328508
e-mail: francesca.novara@unipv.it
e-mail: francesca.novara@microgenomics.it
Birth date: 2 agosto 1981
Born in: Agrigento
Nationality: Italian
ACADEMIC EDUCATION
A.Y. 2000-2001
Enrolment at the University of Pavia, Italy, Faculty of “Biological Mathematical Physical and Natural Sciences“, three-years degree in Biology.
July 29th 2003
Degree in Biology: Human Biology and Biomedical Sciences with a grade of 110/110 and honor.
Degree thesis: “Gli STS (Sequence Tagged Sites) nel genoma umano: analisi mediante PCR (Polymerase Chain Reaction)”, (STSs in the human genome: analysis by PCR). The thesis was carried out in the laboratory of “Human Genetics and Cancers Genetics”, directed by Prof. G. N. Ranzani, at the “Department of Genetics and Microbiology”, University of Pavia.
A.Y. 2003-2004
Enrolment at the University of Pavia, Italy, Faculty of “Biological Mathematical Physical and Natural Sciences“, two years Specialist Degree in “Experimental and Applied Biology: Human Biology and Biomedical Sciences”.
July 26th 2005
Two years specialist degree in “Experimental and Applied Biology: Human Biology and Biomedical Sciences” with a grade of 110/110 and honor.
Title of the thesis: “Evoluzione del cariotipo dei primati: ruolo svolto da una famiglia di sequenze a basso numero di copie localizzata sul cromosoma 9 umano”, (“Evolution karyotype primates: role played by Low Copy Repeats localized on human chromosome 9”). The thesis work was developed in the laboratory of “Human Cytogenetics”, directed by Prof. Elena Raimondi, at the “Department of Genetics and Microbiology”, University of Pavia.
POST-DEGREE EDUCATION
A.Y. 2005-2006
Enrolment at Medical Genetics School (four years school), directed by Prof. O. Zuffardi, University of Pavia, Italy.
A.Y. 2008-2009
Specialization in Medical Genetics.
A.Y. 2009-2010
Enrolment at PDH in Pathology and Medical Genetics School (three years school), directed by Prof. C. Danesino, University of Pavia, Italy (tutor Prof.ssa O. Zuffardi). The research project is based on the analysis of patients with genetic epilepsy to identify genetic alterations correlated to the pathology by array-CGH.
JOBS:
October 2005 – today:
She works in Pre- and Postnatal Cytogenetics diagnosis lab directed by Prof. O. Zuffardi. During these years, she has developed a great skill in array-CGH applied both in constitutional and acquired diseases. During these years he gained extensive experience in the field of array-CGH technique applied in both tumor and constitutional diseases. She is involved in various projects of molecular biology and cytogenetics.
A.Y. 2008-2009:
Owner of a mentoring partnership with the Faculty of Medicine and Surgery, University of Pavia.
March 2009:
Training at the Laboratory of Proteomics and transcriptome (Responsible Prof. Antonino Cattaneo) at the Foundation EBRI (European Brain Research Institute), Rita Levi-Montalcini (Rome) to learn the technique of gene-expression.
A.Y. 2009-2010:
Owner of a mentoring partnership with the Faculty of Medicine and Surgery, University of Pavia.
October 2009 – today:
Amministratore Unico e Tecnico di Laboratorio del Laboratorio di Analisi Genetiche, spin-off dell’Universitą di Pavia, Microgenomics s.r.l. CEO and Technical Laboratory at Microgenomics srl Lab, a spin-off of the University of Pavia.
MEETING PRESENCE
Year 2005
· 7° FISV Meeting, Riva del Garda.
Year 2006
· 2nd International Meeting on Cryptic Chromosomal rearrangements in Mental Retardation and Autism, Troina (Italy).
· 3° Corse in Corso di Formazione in Hematology Oncology, “Malignant Lymphomas: news and progress”, Milan.
Year 2007
· XIV Convention Scientifica Telethon, Salsomaggiore Terme.
· Pan-European Emerging Trends in Hematologic Malignancies, Milan.
· State of the Art Symposia: New opportunity of care for non-Hodgkin lymphomas, Pavia.
· 3rd International Meeting on Cryptic Chromosomal rearrangements in Mental Retardation and Autism, Troina (Italy).
· 6° Course of advanced formation: “Molecular and bioinformatics prediction in hematology / oncology”, Collegio Ghislieri, Pavia.
· ESGH Conference 2007, Nizza.
· X Congresso Nazionale SIGU, Montecatini Terme.
· Course: Set hereditary predisposition to the development of pediatric cancers, Montecatini Terme.
· SIGU Meetings of Genetics Clinic, Napoli.
· Medical Genetic Meeting: Cryptic chromosomal anomalies: analysis trough array-CGH, Varese.
Year 2008
· Meeting: Array-CGH: applications in mental retardation and tumors, Siena.
· XX Course: genetics of epilepsy and genetic epilepsies, Venezia.
· Illumina Symposium “From Whole-Genome to Whole-Solution, Disease Analysis Tools for the Next Generation”, Milano.
· Course: Patients with rare diagnosis: problems, Pavia.
· XI Congresso Nazionale SIGU, Genova.
Year 2009
· XV Convention Telethon, Riva del Garda (TN).
· 5th International Meeting on Cryptic Chromosomal rearrangements in Mental Retardation and Autism, Troina (EN).
· 4th Course in Clinical Cytogenetics, Goldrain Castle, Italy (Faculty member).
· XII Congresso Nazionale SIGU, Torino.
Year 2011
· ECA, 2011, Porto (Portogallo).
· Corso Avanzato di Citogenetica Costituzionale: verso il cariotipo Molecolare? Genova.
· XIV Congresso Nazionale SIGU, Milano.
TECHNIQUE COMPETENCES
Cytogenetics techniques:
– Somatic cell cultures.
– Chromosome preparations from stabilized and non cellular lines.
– Conventional and high resolution in situ hybrydization: FISH on interphase nuclei and metaphase chromosomes
– Optical and in fluorescence microscopy.
– Image processing.
– In situ hybriditation: array-CGH
Biomolecular techniques
– DNA extraction from blood, amniotic fluid, chorionic villi, mononuclear cells separated by bone marrow cell cultures, buccal swabs.
– RNA extraction from blood
– Spectrophotometric tools for quantification of nucleic acids.
– DNA amplification by PCR.
– DNA electrophoresis on agarose gels.
– MS-PCR: choice and design primers, amplification of genomic segment and analysis of results.
– QPCR: choice and design primers, amplification of genomic segment and analysis of results.
– Analysis of genomic database.
– STS analysis using known and not microsatellites.
– Gene mutational analysis with Sanger sequencing.
Basal microbiology tecniques
– Bacterical cultures techniques
– Plasmid and BAC DNA extraction.
Array-CGH
– Sample digestion and labeled.
– Hybridization on oligo platforms (Agilent).
– Use of specific software for scan (Agilent Scanner Control) and data analyses (Feature Extraction, CGH Analytics, genomic Workbench, Agilent).
Gene-expression
– RNA quality controll by BioAnalizer (Agilent).
– Hybridization on oligo platforms (Agilent).
– Use of specific software for scan (Agilent Scanner Control) and data extraction (Feature Extraction, Agilent).
Genomic database
– NCBI, UCSC, Ensembl, Database of Genomic Variants, Eurexpress, Endeavour, String, e-Array, Mutation Taster, ecc.
KNOWN LANGUAGES
English: good.
INFORMATIC KNOWLEDGES
Softwares
Applied: Office 2000, Office XP, Office 2003, Office 2007, Office 2010:
Word: Ottima
PowerPoint: Ottima
Excel: Ottima
Image processing: Adobe Photoshop CS
Array-CGH: Agilent Scanner Control software v7.0
Feature Extraction software v9.1 e v10.1
CGH analytics v3.4.27 e v3.5
Agilent Genomic Workbench Standard Edition 6.5.0.58
Molecular analysis Chromas v1.45
GenScanView 1.1/4
Sequence Scanner v1.0
Peak Scanner software v1.0
Residence: Via Tasso, 48
27100 Pavia
Cell. + 339 1328508
e-mail: francesca.novara@unipv.it
e-mail: francesca.novara@microgenomics.it
Birth date: 2 agosto 1981
Born in: Agrigento
Nationality: Italian
ACADEMIC EDUCATION
A.Y. 2000-2001
Enrolment at the University of Pavia, Italy, Faculty of “Biological Mathematical Physical and Natural Sciences“, three-years degree in Biology.
July 29th 2003
Degree in Biology: Human Biology and Biomedical Sciences with a grade of 110/110 and honor.
Degree thesis: “Gli STS (Sequence Tagged Sites) nel genoma umano: analisi mediante PCR (Polymerase Chain Reaction)”, (STSs in the human genome: analysis by PCR). The thesis was carried out in the laboratory of “Human Genetics and Cancers Genetics”, directed by Prof. G. N. Ranzani, at the “Department of Genetics and Microbiology”, University of Pavia.
A.Y. 2003-2004
Enrolment at the University of Pavia, Italy, Faculty of “Biological Mathematical Physical and Natural Sciences“, two years Specialist Degree in “Experimental and Applied Biology: Human Biology and Biomedical Sciences”.
July 26th 2005
Two years specialist degree in “Experimental and Applied Biology: Human Biology and Biomedical Sciences” with a grade of 110/110 and honor.
Title of the thesis: “Evoluzione del cariotipo dei primati: ruolo svolto da una famiglia di sequenze a basso numero di copie localizzata sul cromosoma 9 umano”, (“Evolution karyotype primates: role played by Low Copy Repeats localized on human chromosome 9”). The thesis work was developed in the laboratory of “Human Cytogenetics”, directed by Prof. Elena Raimondi, at the “Department of Genetics and Microbiology”, University of Pavia.
POST-DEGREE EDUCATION
A.Y. 2005-2006
Enrolment at Medical Genetics School (four years school), directed by Prof. O. Zuffardi, University of Pavia, Italy.
A.Y. 2008-2009
Specialization in Medical Genetics.
A.Y. 2009-2010
Enrolment at PDH in Pathology and Medical Genetics School (three years school), directed by Prof. C. Danesino, University of Pavia, Italy (tutor Prof.ssa O. Zuffardi). The research project is based on the analysis of patients with genetic epilepsy to identify genetic alterations correlated to the pathology by array-CGH.
JOBS:
October 2005 – today:
She works in Pre- and Postnatal Cytogenetics diagnosis lab directed by Prof. O. Zuffardi. During these years, she has developed a great skill in array-CGH applied both in constitutional and acquired diseases. During these years he gained extensive experience in the field of array-CGH technique applied in both tumor and constitutional diseases. She is involved in various projects of molecular biology and cytogenetics.
A.Y. 2008-2009:
Owner of a mentoring partnership with the Faculty of Medicine and Surgery, University of Pavia.
March 2009:
Training at the Laboratory of Proteomics and transcriptome (Responsible Prof. Antonino Cattaneo) at the Foundation EBRI (European Brain Research Institute), Rita Levi-Montalcini (Rome) to learn the technique of gene-expression.
A.Y. 2009-2010:
Owner of a mentoring partnership with the Faculty of Medicine and Surgery, University of Pavia.
October 2009 – today:
Amministratore Unico e Tecnico di Laboratorio del Laboratorio di Analisi Genetiche, spin-off dell’Universitą di Pavia, Microgenomics s.r.l. CEO and Technical Laboratory at Microgenomics srl Lab, a spin-off of the University of Pavia.
MEETING PRESENCE
Year 2005
· 7° FISV Meeting, Riva del Garda.
Year 2006
· 2nd International Meeting on Cryptic Chromosomal rearrangements in Mental Retardation and Autism, Troina (Italy).
· 3° Corse in Corso di Formazione in Hematology Oncology, “Malignant Lymphomas: news and progress”, Milan.
Year 2007
· XIV Convention Scientifica Telethon, Salsomaggiore Terme.
· Pan-European Emerging Trends in Hematologic Malignancies, Milan.
· State of the Art Symposia: New opportunity of care for non-Hodgkin lymphomas, Pavia.
· 3rd International Meeting on Cryptic Chromosomal rearrangements in Mental Retardation and Autism, Troina (Italy).
· 6° Course of advanced formation: “Molecular and bioinformatics prediction in hematology / oncology”, Collegio Ghislieri, Pavia.
· ESGH Conference 2007, Nizza.
· X Congresso Nazionale SIGU, Montecatini Terme.
· Course: Set hereditary predisposition to the development of pediatric cancers, Montecatini Terme.
· SIGU Meetings of Genetics Clinic, Napoli.
· Medical Genetic Meeting: Cryptic chromosomal anomalies: analysis trough array-CGH, Varese.
Year 2008
· Meeting: Array-CGH: applications in mental retardation and tumors, Siena.
· XX Course: genetics of epilepsy and genetic epilepsies, Venezia.
· Illumina Symposium “From Whole-Genome to Whole-Solution, Disease Analysis Tools for the Next Generation”, Milano.
· Course: Patients with rare diagnosis: problems, Pavia.
· XI Congresso Nazionale SIGU, Genova.
Year 2009
· XV Convention Telethon, Riva del Garda (TN).
· 5th International Meeting on Cryptic Chromosomal rearrangements in Mental Retardation and Autism, Troina (EN).
· 4th Course in Clinical Cytogenetics, Goldrain Castle, Italy (Faculty member).
· XII Congresso Nazionale SIGU, Torino.
Year 2011
· ECA, 2011, Porto (Portogallo).
· Corso Avanzato di Citogenetica Costituzionale: verso il cariotipo Molecolare? Genova.
· XIV Congresso Nazionale SIGU, Milano.
TECHNIQUE COMPETENCES
Cytogenetics techniques:
– Somatic cell cultures.
– Chromosome preparations from stabilized and non cellular lines.
– Conventional and high resolution in situ hybrydization: FISH on interphase nuclei and metaphase chromosomes
– Optical and in fluorescence microscopy.
– Image processing.
– In situ hybriditation: array-CGH
Biomolecular techniques
– DNA extraction from blood, amniotic fluid, chorionic villi, mononuclear cells separated by bone marrow cell cultures, buccal swabs.
– RNA extraction from blood
– Spectrophotometric tools for quantification of nucleic acids.
– DNA amplification by PCR.
– DNA electrophoresis on agarose gels.
– MS-PCR: choice and design primers, amplification of genomic segment and analysis of results.
– QPCR: choice and design primers, amplification of genomic segment and analysis of results.
– Analysis of genomic database.
– STS analysis using known and not microsatellites.
– Gene mutational analysis with Sanger sequencing.
Basal microbiology tecniques
– Bacterical cultures techniques
– Plasmid and BAC DNA extraction.
Array-CGH
– Sample digestion and labeled.
– Hybridization on oligo platforms (Agilent).
– Use of specific software for scan (Agilent Scanner Control) and data analyses (Feature Extraction, CGH Analytics, genomic Workbench, Agilent).
Gene-expression
– RNA quality controll by BioAnalizer (Agilent).
– Hybridization on oligo platforms (Agilent).
– Use of specific software for scan (Agilent Scanner Control) and data extraction (Feature Extraction, Agilent).
Genomic database
– NCBI, UCSC, Ensembl, Database of Genomic Variants, Eurexpress, Endeavour, String, e-Array, Mutation Taster, ecc.
KNOWN LANGUAGES
English: good.
INFORMATIC KNOWLEDGES
Softwares
Applied: Office 2000, Office XP, Office 2003, Office 2007, Office 2010:
Word: Ottima
PowerPoint: Ottima
Excel: Ottima
Image processing: Adobe Photoshop CS
Array-CGH: Agilent Scanner Control software v7.0
Feature Extraction software v9.1 e v10.1
CGH analytics v3.4.27 e v3.5
Agilent Genomic Workbench Standard Edition 6.5.0.58
Molecular analysis Chromas v1.45
GenScanView 1.1/4
Sequence Scanner v1.0
Peak Scanner software v1.0
