Università degli studi di Pavia


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Nergadze publications

Papers on peer-reviewed journals

1. Vidale P, Magnani E, Nergadze SG, Santagostino M, Cristofari G, Smirnova A, Chiara Mondello M, Giulotto E. The catalytic and the RNA subunits of human telomerase are required to immortalize equid primary fibroblasts. Chromosoma 2012; 121:475–488. Published online:14 July, 2012; Epub 2012 Jul 14. PubMed PMID: 22797876.
2. Achilli A, Olivieri A, Soares P, Lancioni H, Hooshiar Kashani B, Perego UA, Nergadze SG, Carossa V, Santagostino M, Capomaccio S, Felicetti M, Al-Achkar W, Penedo MCT, Verini-Supplizi A, Houshmand M, Woodward SR, Semino O, Silvestrelli M, Giulotto E, Pereira L, Bandelt H-J, Torroni A. Mitochondrial Genomes from Modern Horses Reveal the Major Haplogroups that Underwent Domestication. Proc Natl Acad Sci U S A. 2012; 109:2449-2454. Epub 2012 Jan 30. PubMed PMID: 22308342.
3. Vidale P, Piras FM, Nergadze SG, Bertoni L, Verini-Supplizi A, Adelson D, Guérin G, Giulotto E. Chromosomal assignment of six genes (EIF4G3, HSP90, RBBP6, IL8, TERT, and TERC) in four species of the genus Equus. Anim Biotechnol. 2011; 22:119-123. PubMed PMID: 21774619.
4. Raimondi E, Piras FM, Nergadze SG, Di Meo GP, Ruiz-Herrera A, Ponsà M, Ianuzzi L, Giulotto E. Polymorphic organization of constitutive heterochromatin in Equus asinus (2n = 62) chromosome 1. Hereditas. 2011; 148:110-113. Epub 2011 May 12. PubMed PMID: 21756256.
5. Ruiz-Herrera A, Smirnova A, Khoriauli L, Nergadze SG, Chiara Mondello C, Giulotto E. Gene amplification in human cells knocked down for RAD54. Genome Integrity. 2011; 2:5. PubMed PMID: 21418575.
6. Nergadze SG, Lupotto M, Pellanda P, Santagostino M, Vitelli V, Giulotto E. Mitochondrial DNA insertions in the nuclear horse genome. Animal Genetics. 2010 (Invited submission, special issue of Animal Genetics) 41 Suppl 2:176-85. PubMed PMID: 21070293.
7. Piras FM*, Nergadze SG*, Magnani E, Bertoni L, Attolini C, Khoriauli L, Raimondi E, Giulotto E. Uncoupling of Satellite DNA and Centromeric Function in the Genus Equus. PLoS Genet. 2010; 6: e1000845. (*, These authors contributed equally to this work). PubMed PMID: 20169180.
8. Nergadze SG, Farnung BO, Wischnewski H, Khoriauli L, Vitelli V, Chawla R, Giulotto E, Azzalin CM. CpG-island promoters drive transcription of human telomeric repeat-containing RNA. RNA. 2009; 15: 2186-2194. Epub 2009 Oct 22. PubMed PMID: 19850908.
9. Wade CM, Giulotto E, Sigurdsson S, Zoli M, Gnerre S, Imsland F, Lear TL, Adelson DL, Bailey E, Bellone RR, Blöcker H, Distl O, Edgar RC, Garber M, Leeb T, Mauceli E, MacLeod JN, Penedo MCT, Raison JM, Sharpe T, Vogel J, Andersson L, Antczak DF, Biagi T, Binns MM, Chowdhary BP, Coleman SJ, Della Valle G, Fryc S, Guérin G, Hasegawa T, Hill EW, Jurka J, Kiialainen A, Lindgren G, Liu J, Magnani E, Mickelson JR, Murray J, Nergadze SG, Onofrio R, Pedroni S, Piras MF, Raudsepp T, Rocchi M, Røed KH, Ryder OA, Searle S, Skow L, Swinburne JE, Syvänen AC, Tozaki T, Valberg SJ, Vaudin M, White JR, Zody MC, Broad Institute Genome Sequencing Platform, Broad Institute Whole Genome Assembly Team, Lander ES, and Lindblad-Toh K. Genome sequence, comparative analysis and population genetics of the domestic horse (Equus caballus). Science. 2009; 326: 865-867. PubMed PMID: 19892987.
10. Piras M, Nergadze SG, Poletto V, Cerutti F, Ryder OA, Leeb T, Raimondi E, Giulotto E. Phylogeny of horse chromosome 5 in the genus Equus and centromere repositioning. Cytogenet Genome Res. 2009; 126: 165-172. Epub 2009 Dec 9. PubMed PMID: 20016166.
11. Rebuzzini P, Castiglia R, Nergadze SG, Mitsainas G, Munclinger P, Zuccotti M, Capanna E, Redi CA, Garagna S. Quantitative variation of LINE-1 sequences in five species and three subspecies of the subgenus Mus and in five Robertsonian races of Mus musculus domesticus. Chromosome Res. 2009; 17: 65-76. Epub 2009 Jan 31. PubMed PMID: 19184476.
12. Salzano A, Kochiashvili N, Nergadze SG, Khoriauli L, Smirnova A, Ruiz-Herrera A, Mondello C, Giulotto E. Enhanced gene amplification in human cells knocked down for DNA-PKcs. DNA Repair. 2009; 8: 19-28. Epub 2008 Oct 21. PubMed PMID: 18832050.
13. Ruiz-Herrera A, Nergadze SG, Santagostino M, Giulotto E. Telomeric repeats far from the ends: mechanisms of origin and role in evolution. Cytogenet Genome Res. 2008; 122: 219-228. Epub 2009 Jan 30. Review. PubMed PMID: 19188690.
14. Nergadze SG, Santagostino M, Salzano A, Mondello C, Giulotto E. Contribution of telomerase RNA retrotranscription to DNA double-strand break repair during mammalian genome evolution. Genome Biol. 2007; 8: R260. PubMed PMID: 18067655.
15. Carbone L, Nergadze SG, Magnani E, Misceo D., Cardone MF, Roberto R, Bertoni L, Attolini C, Piras MF, de Jong P, Raudsepp T, Chowdhary BP, Guérin G, Archidiacono N, Rocchi M, Giulotto E. Evolutionary movement of centromeres in horse, donkey, and zebra. Genomics. 2006; 87: 777-782. PubMed PMID: 16413164.
16. Nergadze SG, Magnani E, Attolini C, Bertoni L, Adelson DL, Cappelli K, Verini Supplizi A, Giulotto E. Assignment of the Equus caballus interleukin 8 gene (IL8) to chromosome 3q14.2→q14.3 by in situ hybridization. Cytogenet Genome Res. 2006; 112: 341B. PubMed PMID: 16484794.
17. Nergadze SG, Rocchi M, Azzalin CM, Mondello C, Giulotto E. Insertion of Telomeric Repeats at Intrachromosomal Break Sites During Primate Evolution. Genome Res. 2004; 14: 1704-1710. PubMed PMID: 15310657.
18. Azzalin CM, Nergadze SG, Giulotto E. Human intrachromosomal telomeric-like repeats: sequence organization and mechanisms of origin. Chromosoma. 2001; 110:75-82. PubMed PMID: 11453557.
19. Barenfeld LS, Nergadze SG, Mikhelson VM. [Decreased frequency of activation of replicon clusters in Down syndrome lymphocytes]. Tsitologiia. 2001; 43:692-697. PubMed PMID: 11552652.
20. Barenfeld LS, Nergadze SG, Pleskach N, Procofjeva V, Mikhelson VM. Decreased number of simultaneously operating adjacent clusters of replicons in some human strains with and without X-irradiation. Mutat Res. 1998; 408:219-226. PubMed PMID: 9806420.
21. Bertoni L, Zoli W, Mucciolo E, Ricotti L, Nergadze SG, Amadori D, Giulotto E. Different genome organization in two new cell lines established from human gastric carcinoma. Cancer Genet Cytogenet. 1998; 105: 152-159. PubMed PMID: 9723033.
22. Barenfel'd LS, Nergadze SG, Pleskach N, Mikhel'son VM. [The mechanism of radioresistant DNA synthesis in ataxia-telangiectasia]. Tsitologiia. 1997; 39:20-24. PubMed PMID: 9173623.
23. Barenfeld LS, Nergadze SG, Pleskach N, Mikhelson VM. Slower synthesis of individual replicons and adjacent replicon clusters in a radiosensitive xeroderma pigmentosum strain with and without X-irradiation. Int J Radiat Biol. 1995; 68:169-76. PubMed PMID: 7658142.
24. Barenfel'd LS, Nergadze SG, Pleskach N, Mikhel’son VM. [The retardation of DNA synthesis in adjacent replicon clusters in the lymphocytes of patients with Down's syndrome as a model of premature aging]. Tsitologiia. 1995; 37:900-4. PubMed PMID: 8815603.
25. Barenfel'd LS, Nergadze SG, Pleskach N, Mikhel’son VM. [The relation of the characteristics of DNA replication to cell sensitivity to ionizing radiation in xeroderma pigmentosum in form II (XP2CP)]. Tsitologiia. 1994; 36: 680-6. PubMed PMID: 7900208.
26. Nergadze SG, Pleskach N, Mikhelson VM, Prokof'eva V, Barenfel'd LS. [DNA replication in intact and X-ray-irradiated cells in the Cockayne syndrome]. Tsitologiia. 1993; 35:24-29. PubMed PMID: 8266580.
27. Barenfel'd LS, Nergadze SG, Pleskach N, Mikhel'son VM. [The interrelation between changes in the structural organization of replicon clusters, a retarded fork displacement rate and the high level of spontaneous SCEs in form II of xeroderma pigmentosum]. Tsitologiia. 1992; 34:88-94. PubMed PMID: 1455562.
28. Khachapuridze GG, Nergadze SG, Lapiashvili N, Panieva I, Barenfel'd LS, Pleskach N, Imedadze MSh. [The effect of staphylococcal alpha-toxin on DNA replication in human cells]. Tsitologiia. 1991; 33:82-89. PubMed PMID: 1821501.
29. Barenfel'd LS, Nergadze SG, Andreeva LF, Pleskach N. [The action of ionizing radiation on DNA replication in the cells of a healthy human subject and of a patient with Down's syndrome]. Tsitologiia. 1989; 31:1377-1384. PubMed PMID: 2534004.
30. Barenfeld LS, Nergadze SG, Pleskach N, Mikhelson VM, Andreeva LF, Bil'din NV. [Disruption of DNA replication in non-irradiated cells in basal cell nevus syndrome and the effect of ionizing radiation]. Tsitologiia. 1989; 31:775-784. PubMed PMID: 2815337.
31. Nergadze SG, Khachapuridze GG, Kacharava T, Imedadze MSh, Tsintsadze MA. [Changes in the cytogenetic indices in the bone marrow cells of white rats undergoing mechanical trauma of various degrees of severity]. Tsitologiia. 1988; 30:495-498. PubMed PMID: 3413834.

Papers on journals without peer-reviewing

1. Tupler R, Giulotto E, Nergadze S, Azzalin C. (1999) Genomic organization of genes differentially expressed in the FSHD muscle. FSH Watch. 6, 19. (pp. 17).
2. Nergadze SG, Barenfel'd LS. (1995), Different structural organization for cluster of replicons in some human cell strains and different inhibition of DNA replication by ionizing radiation. Geor. J. Genet. Ecol., 1:4-11
3. Beldishevski M, Nergadze SG, Khachapuridze GG, Brelidze ZL. (1992) Image processing automation of fibre autoradiograms. In: "MEDINFO 92", K.G.LuN, P.Degoulet, T. Piemme, O. reinhoff (eds), Amsterdam, North-Holland, p. 818-820.
4. Barenfeld LS, Nergadze SG, Pleskach N, Mikhelson VM. (1992) DNA replication and sister chromatid exchanges in Xeroderma Pigmentosum (Form II). Ecogen. 7:10-12
5. Nergadze SG, Barenfel’d LS. (1992) Decrease rate of DNA chain growth in Down syndrome lymphocytes. Ecogen, 6:12-14.
6. Nergadze SG, Khachapuridze GG, Kacharava T, Mikhel'son VM, Lukina N. (1989), [Study of the role of reparation systems in cytological effects of hyperthermia] Proc. Acad. Sci. of Georgia, 15:196-198.
7. Nergadze SG, Khachapuridze GG, Kacharava T, Lukina N, Tsintsadze M. (1989), [The influence of hyperthermia on the frequency of chromosome aberration in human lymphocytes on various stages of cell cycle]. Proc. Acad. Sci. Georgia, 15:127-130.

Meeting abstracts (only from 2007)

1. Giulotto E, Khoriauli L, Santagostino M, Vella F, Gamba R, Klipstein O, Raimondi E, Nergadze S (2012) Insertion of ERE elements in the horse genome and gene expression regulation. Plant and Animal Genome XX Conference. San Diego, California (USA) January 14-18, 2012.
2. Santagostino M, Nergadze SG, Klipstein O, Maniezzi C, Bonomi S, Biamonti G, Ghigna, C, Giulotto, E. (2011) Interstitial telomeric repeats in the regulation of gene expression and in genome stability. FEBS JOURNAL 278 (Special Issue; Supplement 1): 89-89.
3. Lupotto, M, Vidale P, Smirnova A, Nergadze SG, Chiodi I, Santagostino M, Mondello C, Giulotto E. (2011) Telomerase activation in ALT cells. FEBS JOURNAL 278 (Special Issue; Supplement 1): 219-219.
4. Vitelli V, Nergadze S, Khoriauli L, Lupotto, M, Azzalin C, Giulotto, E. (2011) Human telomeres are transcribed from a CpG island promoter and isolated from the subtelomeric context. FEBS JOURNAL 278 (Special Issue; Supplement 1): 90-90.
5. Olivieri A, Achilli A, Lancioni H, Hooshiar Kashani B, Perego UA, Nergadze SG, Carossa V, Santagostino M, Capomaccio S, Felicetti M, Verini-Supplizi A, Woodward SR, Semino O, Silvestrelli M, Giulotto E, Torroni A (2011). Horse mitochondrial genomes: at least 17 matrilineal lineages underwent domestication. Joint Meeting AGI-SIBV-SIGA, Cittadella di Assisi (PG) (Italy) , September 19th-22th.
6. Nergadze S. G., M. Lupotto, P. Pellanda, M. Santagostino, V. Vitelli, E. Giulotto (2010) High frequency of telomeric repeats and mitochondrial DNA insertions in the horse genome. Conference for the International Society for Animal Genetics, Edinburgh, Scotland, 26 – 30 July 2010.
7. Vitelli V., S.G. Nergadze, L. Khoriauli, M. Lupotto, C.M. Azzalin, E. Giulotto. (2009) A GC-rich minisatellite drives transcription of human telomeres. FISV 11th Annual Congress, Riva del Garda (TN), Italy, 23-25 September 2009 (P24.8).
8. Piras M.F., S.G. Nergadze, E. Magnani, L. Bertoni, C. Attolini, E. Raimondi, E. Giulotto (2009) Evolutionary novel centromeres in the genus equus. FISV 11th Annual Congress, Riva del Garda (TN), Italy, 23-25 September 2009 (P4.6).
9. Vidale P., E. Magnani, S.G. Nergadze, Mondello, E. Giulotto. (2009) Ectopic expression of human telomerase allows the immortalization of primary cells from equus species. FISV 11th Annual Congress, Riva del Garda (TN), Italy, 23-25 September 2009 (P4.7).
10. Ruiz-Herrera A, Smirnova A, Khoriauli L, Nergadze SG, Mondello C, Giulotto E. (2009) Estudio de la amplificacion genica en lineas celulares humanas defectivas en los mecanizmos de reparacion del ADN. XVIII Reunion Cienetica de la Socidad Espanola de Mutagenesis Ambiental - SEMA2009, Ballaterra, 29 de Junio - 1 de Julio, 2009. (p. 39).
11. Giulotto E, Piras MF, Nergadze SG, Della Valle G, Zoli M, Leeb T, Magnani E, Gnerre S, Rocchi M, Bertoni L, Attolini C. (2009) Molecular characterization of an evolutionary novel horse centromere. Plant & Animal Genomes XVII Conference, San Diego, California, 10-14 January, 2009.
12. Magnani E, Vidale P, Nergadze SG, Cristofari G, Mondello C, Giulotto E. (2008) Both subunits of human telomerase are required to immortalize primary fibroblasts from equus species. EMBO Meeting "Telomeres and the DNA damage response" Villars-sur-Ollon, Switzerland, 15 - 19 September, 2008.
13. Magnani E., Vidale P., Nergadze SG, Mondello C, Giulotto E. (2008) Immortalization Of Primary Fibroblasts From Equus Species By Ectopic Expression Of Human Telomerase. Plant & Animal Genomes XVI Conference, San Diego, California, January 12-16, (pp. 588).
14. Alaoui N, Jordana J, Magnani E, Nergadze SG, Giulotto E, Ponsa M. (2007) New polymorphism in heterochromatin regions of Equus asinus chromosomes detected by horse DNA satellite probes. 6th European Cytogenetic Conference, Istanbul, Turkey, 7-10 July; CHROMOSOME RESEARCH 15: 130-131 Suppl. 1, 2007, IF: 3.130.
15. Nergadze SG, Khoriauli L, Rocchi M, Semino O, Mondello C, Giulotto E. (2007) Evolution and instability of a human interstitial telomeric repeat organized in a head-to-head fashion. FISV 9th Annual Congress. Riva del Garda, Italy, 26-29 September, (pp D07.3)
16. Nergadze SG, Mondello C., Giulotto E. (2007) Interstitial Telomeric Repeats: A New Class Of Polymorphic Markers In The Horse Genome. Plant & Animal Genomes XV Conference, San Diego, California, January 13-17, (pp. P588).
17. Nergadze SG, Santagostino M, Mondello C, Giulotto E. (2007) Insertion of telomerase RNA retrotranscripts at DNA double-strand break sites during mammalian genome evolution. “The Role of Telomeres and Telomerase in Cancer Research.” Hyatt Regency San Francisco,
San Francisco, California. December 6 – 9 (pp B31).
18. Nergadze SG, Santagostino M, Mondello C, Giulotto E. (2007) Interstitial Telomeric Repeats in the Horse Genome: Molecular Markers for Population Genetics, Paternity Testing and Phylogenetic Studies. 7th Havemeyer Horse Genome Workshop. Lake Tahoe, CA, August 16-19.
19. Santagostino M., Nergadze SG, Mininni N., Garagna S., Chevret P., Britton-Davidian J., Mondello C., Giulotto E. (2007) Involvement of telomerase in DNA double-strand break repair: an evolutionary approach. FISV 9th Annual Congress. Riva del Garda, 26-29 September. (pp. D07.3).
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