Universitą degli studi di Pavia


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Orioli research activity

Extensive experience and publication record in the field of molecular biology and biochemistry, with special emphasis on nervous system development in mammals. In the last years, her research has been focusing on the human syndromes xeroderma pigmentosum (XP), trichothiodistrophy (TTD) and Cockayne Syndrome (CS), which result from defects in nucleotide excision repair (NER), a versatile system that removes a wide range of lesions, including UV photoproducts. By microarray analysis, she has recently identified genes specifically deregulated in primary skin fibroblasts derived from TTD patients. The analysis has allowed to identify alterations in the extracellular matrix of TTD cells that could explain some of TTD clinical symptoms and to define new functions of the repair/transcription complex TFIIH in transcription.

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