Universitą degli studi di Pavia


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Nergadze research activity

Research projects in mammalian genome integrity maintenance mechanisms:

- Centromere function and evolution
- Telomere transcription
- Telomerase and DNA Repair
- Interstitial telomeric sequences in mammalian genomes
- Mitochondrial DNA insertions in the nuclear horse genome

Most relevant projects in the past:

- Immortalization of primary fibroblasts from equus species through an ectopic expression of the human telomerase;
- Gene amplification in DNA-PKcs inhibited cells using the RNAi approach;
- Genome organization of cell lines established from human gastric carcinoma;
- Telomeres and cell senescence;
- DNA replication in irradiated cells from patients with inherited diseases of chromosome instability.

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